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pentobarbital will lessen the extent or result of guanfacine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Closely. Powerful or moderate CYP3A4 inducers appreciably decrease guanfacine plasma concentrations and elimination 50 %-life.pentobarbital will lessen the extent or effect of alosetron by affecting hepatic/i